p62 at the crossroads of autophagy, apoptosis, and cancer.
review · Level V
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- Record sourced from PubMed, PMID 19524504.
- Also identified by DOI 10.1016/j.cell.2009.05.023 and PMC identifier 3971861.
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Abstract
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Apoptosis
- Autophagy
- Neoplasms