InterMap3D: predicting and visualizing co-evolving protein residues.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19528088.
- Also identified by DOI 10.1093/bioinformatics/btp335.
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Abstract
InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted. http://www.cbs.dtu.dk/services/InterMap3D/.
Medical subject headings
- Computational Biology
- Proteins
- Software