Observations on cryoglobulin testing: II. The association of oligoclonal mixed cryoglobulinemia with cirrhosis in patients infected with hepatitis C virus.

De Rosa, Francesco G; Abel, György; Agnello, Vincent · J Rheumatol · 2009

case_control · Level III

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Abstract

To determine whether a mixed cryoglobulin type correlated with cirrhosis in patients infected with hepatitis C virus (HCV). We investigated the results of mixed cryoglobulin tests performed in the clinical laboratory on patients with and without HCV infection. A higher prevalence of oligoclonal cryoglobulins designated Type IIa was present in HCV-infected patients with cirrhosis than in those without cirrhosis. An association of Type IIa cryoglobulins with cirrhosis in HCV-infected patients has not previously been reported.

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