Discovery of functional miRNA-mRNA regulatory modules with computational methods.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19535005.
- Also identified by DOI 10.1016/j.jbi.2009.01.005.
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Abstract
The identification of miRNAs and their target mRNAs and the construction of their regulatory networks may give new insights into biological procedures. This study proposes a computational method to discover the functional miRNA-mRNA regulatory modules (FMRMs), that is, groups of miRNAs and their target mRNAs that are believed to participate cooperatively in post-transcriptional gene regulation under specific conditions. The proposed method identifies negatively regulated patterns of miRNAs and mRNAs which associate with cancer and normal conditions, respectively, in a prostate cancer data set. GO and the literature also suggest that they may relate with prostate cancer. It can potentially identify the biologically relevant chains of 'miRNA-->target gene --> condition'.
Medical subject headings
- Algorithms
- Computational Biology
- Gene Regulatory Networks
- Information Storage and Retrieval
- MicroRNAs
- RNA, Messenger