Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.
basic_science · Level V
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- Record sourced from PubMed, PMID 19541956.
- Also identified by DOI 10.1126/science.1173155 and PMC identifier 2865899.
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Abstract
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
Medical subject headings
- Amyloid
- Peptide Hormones
- Pituitary Gland
- Pituitary Hormones
- Secretory Vesicles