Colorectal cancer screening with CT colonography: key concepts regarding polyp prevalence, size, histology, morphology, and natural history.

Abstract

The purpose of this article is to provide a timely update on a variety of key polyp topics to construct a proper framework for physicians who are interested in providing CT colonography screening as a clinical service. As the medical community considers the expansion of CT colonography for screening, we believe it is prudent to update and review several key concepts regarding colorectal polyps. In particular, it is important to replace the older literature derived from high-risk and symptomatic cohorts with the wealth of newer and more applicable data from average-risk and asymptomatic screening cohorts. Familiarity with current concepts regarding flat (nonpolypoid) lesions and the natural history of small colorectal polyps is also vital to the effective application of this technique.