Posttransplant anemia: the role of sirolimus.

Fishbane, Steven; Cohen, David J; Coyne, Daniel W; Djamali, Arjang; Singh, Ajay K; Wish, Jay B · Kidney Int · 2009

review · Level V

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Abstract

Posttransplant anemia is a common problem that may hinder patients' quality of life. It occurs in 12 to 76% of patients, and is most common in the immediate posttransplant period. A variety of factors have been identified that increase the risk of posttransplant anemia, of which the level of renal function is most important. Sirolimus, a mammalian target of rapamycin inhibitor, has been implicated as playing a special role in posttransplant anemia. This review considers anemia associated with sirolimus, including its presentation, mechanisms, and management.

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