Breakdown in epithelial barrier function in patients with asthma: identification of novel therapeutic approaches.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19560576.
- Also identified by DOI 10.1016/j.jaci.2009.05.037.
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Abstract
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure.
Medical subject headings
- Asthma
- Immune System
- Pharmaceutical Preparations
- Respiratory Mucosa
- Virus Diseases