The juxtamembrane region of EGFR takes center stage.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19563749.
- Also identified by DOI 10.1016/j.cell.2009.06.008.
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Abstract
The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.
Medical subject headings
- ErbB Receptors