Closing in on mechanisms of tissue morphogenesis.

Rauzi, Matteo; Lecuit, Thomas · Cell · 2009

basic_science · Level V

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Abstract

It remains largely unknown how large-scale tissue movements during development emerge from the interplay of different tensile forces associated with actomyosin networks. Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit fly Drosophila.

Medical subject headings