Interactions between angiotensin II and arginine vasopressin in water homeostasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 19564856.
- Also identified by DOI 10.1038/ki.2009.103 and PMC identifier 4319672.
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Abstract
Mice deficient in the angiotensin II type 1a (AT(1a)) receptor demonstrate a vasopressin-resistant nephrogenic diabetes insipidus. These knockout mice exhibit a threefold increase in 24-h urine excretion. Neither 2 weeks of exogenous vasopressin nor 5 days of fluid restriction reversed this polyuric state. This nephrogenic diabetes insipidus was associated with reductions in adenylyl cyclase protein and in the phosphorylated mitogen-activated protein kinase extracellular signal-regulated kinase 1/2. The results support an important interaction between vasopressin and angiotensin II in maximal urinary concentration.
Medical subject headings
- Angiotensin II
- Arginine Vasopressin
- Diabetes Insipidus, Nephrogenic
- Receptor, Angiotensin, Type 1
- Water-Electrolyte Balance