Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 19567621.
- Also identified by DOI 10.3899/jrheum.080737 and PMC identifier 2798588.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To study anti-Ro/La-negative congenital heart block (CHB). Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.
Medical subject headings
- Antibodies, Antinuclear
- Atrioventricular Block
- Autoantigens
- Pregnancy Complications
- Ribonucleoproteins