Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells.

Kojima, Ryota; Yoshimoto, Keitaro; Takahashi, Emiko; Ichino, Masahiro; Miyoshi, Hirotoshi; Nagasaki, Yukio · Lab Chip · 2009

basic_science · Level V

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Abstract

A spheroid array of fetal mouse liver cells, which comprise various immature cells, was constructed on a PEG-gel micropatterned surface and its hepatic activity and degree of differentiation induction were significantly upregulated by co-culture with nonparenchymal liver cells as feeder-cells.

Medical subject headings