SKP-ing TAp63: stem cell depletion, senescence, and premature aging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19570504.
- Also identified by DOI 10.1016/j.stem.2009.06.015.
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Abstract
The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial development. In this issue of Cell Stem Cell, by generating isoform-specific knockout mice, Su et al. (2009) reveal pivotal roles for TAp63 in the maintenance of dermal and epidermal precursors, genomic stability, and organismal longevity.
Medical subject headings
- Aging, Premature
- Cellular Senescence
- Phosphoproteins
- Skin
- Stem Cells
- Trans-Activators