Stem cell aging and aberrant differentiation within the niche.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19570507.
- Also identified by DOI 10.1016/j.stem.2009.06.006.
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Abstract
Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.
Medical subject headings
- Cell Differentiation
- Cellular Senescence
- Stem Cell Niche
- Stem Cells