HI: haplotype improver using paired-end short reads.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19570807.
- Also identified by DOI 10.1093/bioinformatics/btp412 and PMC identifier 2735667.
- Licence recorded as CC BY-NC.
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Abstract
We present a program to improve haplotype reconstruction by incorporating information from paired-end reads, and demonstrate its utility on simulated data. We find that given a fixed coverage, longer reads (implying fewer of them) are preferable. The executable and user manual can be freely downloaded from ftp://ftp.sanger.ac.uk/pub/zn1/HI.
Medical subject headings
- Computational Biology
- Haplotypes
- Software