Elite and stochastic models for induced pluripotent stem cell generation.
basic_science · Level V
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- Record sourced from PubMed, PMID 19571877.
- Also identified by DOI 10.1038/nature08180.
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Abstract
Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
Medical subject headings
- Cellular Reprogramming
- Models, Biological
- Pluripotent Stem Cells