Porcine gelatin microsphere/calcium phosphate cement composites: an in vitro degradation study.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19582834.
- Also identified by DOI 10.1002/jbm.b.31429.
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Abstract
Scaffolds for bone tissue engineering preferably should be mechanically stable, osteoconductive, biodegradable and porous. To comply with these characteristics, calcium phosphate cements (CPCs) with porcine (type A) gelatin microspheres were formulated. In this experiment, in vitro degradation of 10 wt % gelatin type A microsphere CPCs (GELA CPCs) was followed for 12 weeks in proteolytic medium. Results showed a gradual decrease in mass, compression strength and E-modulus. Morphology investigation showed that degradation of the spheres started at the surface of the composite and gradually proceeded to the inner part. Overall, porcine gelatin microspheres can be used to generate in situ macroporosity into an injectable CPC.
Medical subject headings
- Absorbable Implants
- Bone Cements
- Calcium Phosphates
- Gelatin
- Tissue Scaffolds