Spreading the wealth: Niemann-Pick type C proteins bind and transport cholesterol.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19583946.
- Also identified by DOI 10.1016/j.cmet.2009.06.007.
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Abstract
Endocytosed cholesterol must be transferred from the environment (e.g., low-density lipoproteins) via the lysosomal system to the rest of the cell. In Niemann-Pick type C disease, this process fails. In a recent issue of Cell, Kwon et al. (2009) suggest how this transpires mechanistically by crystallizing a domain of a protein defective in this syndrome.
Medical subject headings
- Carrier Proteins
- Cholesterol
- Membrane Glycoproteins