A crystallized view of AMPK activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19583947.
- Also identified by DOI 10.1016/j.cmet.2009.06.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
AMP-activated protein kinase (AMPK) is a key metabolic regulator. Recent work (Chen et al., 2009) elucidates the structural interaction between the autoinhibitory sequence and the kinase domain of the AMPK catalytic subunit. Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches.
Medical subject headings
- AMP-Activated Protein Kinases