The gutsy side of bone.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19583948.
- Also identified by DOI 10.1016/j.cmet.2009.06.004.
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Abstract
Though surgical removal of the stomach has long been linked to low bone mass, the molecular mechanism has been elusive. Amling and coworkers now demonstrate that gastric cell acid production is necessary for calcium absorption. Mice lacking this acidification develop hypocalcemia, with increased parathyroid hormone and osteoclast differentiation, and decreased bone mass.
Medical subject headings
- Bone Density
- Calcium
- Gastric Mucosa