Targeting lymphotoxin depletes pathogenic T cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19584860.
- Also identified by DOI 10.1038/nm0709-732 and PMC identifier 2757749.
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Abstract
A monoclonal antibody directed against lymphotoxin-α (LT-α) expressed by pathogenic T cells can prompt the clearance of these cells from the body (pages 766–773). The findings bring us one step closer to targeting only the cell populations that cause harm in autoimmune diseases while leaving beneficial arms of the immune system largely intact.
Medical subject headings
- Antibodies, Monoclonal
- Autoimmune Diseases
- Interleukin-17
- Lymphocyte Depletion
- Lymphotoxin-alpha
- Th1 Cells