The effect of tissue culture on suture holding strength and degradation in canine tendon.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19587082.
- Also identified by DOI 10.1177/1753193409104564 and PMC identifier 3694784.
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Abstract
The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.
Medical subject headings
- Forelimb
- Sutures
- Tendons