Kinetics of pertussis immune responses to tetanus-diphtheria-acellular pertussis vaccine in health care personnel: implications for outbreak control.

Kirkland, Kathryn B; Talbot, Elizabeth A; Decker, Michael D; Edwards, Kathryn M · Clin Infect Dis · 2009

prospective_cohort · Level II

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Abstract

We assessed the kinetics of the humoral immune response to pertussis antigens following vaccination of health care personnel with adult tetanus-diphtheria-acellular pertussis vaccine (Tdap). By 2 weeks after vaccination, 88%-94% of subjects demonstrated a booster response. This brisk response of adults to Tdap supports a role for vaccination in pertussis outbreak control.

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