Variation in the safety of induced pluripotent stem cell lines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19590502.
- Also identified by DOI 10.1038/nbt.1554.
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Abstract
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.
Medical subject headings
- Pluripotent Stem Cells
- Safety