Calorie restriction alters mitochondrial protein acetylation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19594485.
- Also identified by DOI 10.1111/j.1474-9726.2009.00503.x and PMC identifier 2752488.
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Abstract
Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro-longevity CR response.
Medical subject headings
- Caloric Restriction
- Longevity
- Mammals
- Mitochondria
- Mitochondria, Liver
- Proteins
- Saccharomycetales