Teeing up transcription on CpG islands.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19596228.
- Also identified by DOI 10.1016/j.cell.2009.06.028.
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Abstract
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al., 2009; Hargreaves et al., 2009).
Medical subject headings
- CpG Islands
- Transcriptional Activation