Disorder, promiscuity, and toxic partnerships.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19596229.
- Also identified by DOI 10.1016/j.cell.2009.06.024 and PMC identifier 2848715.
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Abstract
Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
Medical subject headings
- Gene Expression
- Proteins