Chromatin places metabolism center stage.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19596230.
- Also identified by DOI 10.1016/j.cell.2009.06.025.
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Abstract
Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science (Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connection between central metabolism and mammalian gene expression.
Medical subject headings
- Acetyl Coenzyme A
- Chromatin
- Gene Expression Regulation
- Glucose