Metabolic network analysis integrated with transcript verification for sequenced genomes.
basic_science · Level V
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- Record sourced from PubMed, PMID 19597503.
- Also identified by DOI 10.1038/nmeth.1348 and PMC identifier 3139173.
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Abstract
With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we describe a systems-level methodology bridging metabolic network reconstruction with experimental verification of enzyme encoding open reading frames. Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering.
Medical subject headings
- Chlamydomonas reinhardtii
- Computational Biology
- Genome, Protozoan
- Models, Genetic
- Protozoan Proteins
- Transcription, Genetic