GAL4 is phosphorylated as a consequence of transcriptional activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 1961715.
- Also identified by PMC identifier 52958.
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Abstract
GAL4 protein isolated from yeast in which it is active is phosphorylated predominantly on two different serine residues. One of these was identified as Ser-837; substitution of this residue for alanine has no detectable effect on transcriptional activation by GAL4. Phosphorylation at Ser-837 requires that both the DNA binding and transcriptional activation functions be intact. We propose that some phosphorylations of GAL4, including that at Ser-837, occur concomitantly with activation of transcription.
Medical subject headings
- Fungal Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transcription, Genetic