The genetic and molecular regulation of sleep: from fruit flies to humans.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19617891.
- Also identified by DOI 10.1038/nrn2683 and PMC identifier 2767184.
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Abstract
It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens have identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects gene expression. These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.
Medical subject headings
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Sleep