Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.
review · Level V
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- Record sourced from PubMed, PMID 19623690.
- Also identified by PMC identifier 2797310.
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Abstract
Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.
Medical subject headings
- Immunotherapy
- Interleukin-7
- T-Lymphocytes