Cell death: a new Par-4 the TRAIL.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19632170.
- Also identified by DOI 10.1016/j.cell.2009.07.007.
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Abstract
The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum stress.
Medical subject headings
- Apoptosis
- Receptors, Thrombin