Navigating the deubiquitinating proteome with a CompPASS.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19632171.
- Also identified by DOI 10.1016/j.cell.2009.07.008.
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Abstract
Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
Medical subject headings
- Endopeptidases
- Proteome
- Software