A new therapeutic target for leukemia comes to the surface.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19632173.
- Also identified by DOI 10.1016/j.cell.2009.07.005.
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Abstract
Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. In this issue, Jaiswal et al. (2009) and Majeti et al. (2009) show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for patients with acute myeloid leukemia.
Medical subject headings
- CD47 Antigen
- Leukemia, Myeloid, Acute
- Neoplastic Stem Cells
- Phagocytosis