An integrated microfluidic device for large-scale in situ click chemistry screening.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19636457.
- Also identified by DOI 10.1039/b907430a and PMC identifier 2878189.
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Abstract
An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.
Medical subject headings
- Microfluidic Analytical Techniques
- Systems Integration