Tumor endothelial cells join the resistance.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19638456.
- Also identified by DOI 10.1158/1078-0432.CCR-09-0902 and PMC identifier 2729656.
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Abstract
The field of antiangiogenesis research has been met with some surprises, including the realization that tumor blood vessels are more complex and labile than expected. In this issue of Clinical Cancer Research, Xiong and colleagues show that tumor-specific endothelial cells are less sensitive to cytotoxic and antiangiogenic drugs compared to their normal counterparts.
Medical subject headings
- Angiogenesis Inhibitors
- Carcinoma, Hepatocellular
- Drug Resistance, Neoplasm
- Endothelium, Vascular
- Liver Neoplasms
- Neovascularization, Pathologic