A high-performance nanobio photocatalyst for targeted brain cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19640002.
- Also identified by DOI 10.1021/nl901610f and PMC identifier 4019973.
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Abstract
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO(2) particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
Medical subject headings
- Antibodies, Monoclonal
- Brain Neoplasms
- Hydroquinones
- Nanoparticles
- Titanium