Recent progress in the biology and physiology of sirtuins.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19641587.
- Also identified by DOI 10.1038/nature08197 and PMC identifier 3727385.
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Abstract
The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.
Medical subject headings
- Sirtuins