MicroRNAs and parallel stem cell lives.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19665962.
- Also identified by DOI 10.1016/j.cell.2009.07.025.
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Abstract
A new study by Shimono et al. (2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells.
Medical subject headings
- MicroRNAs
- Neoplastic Stem Cells
- Stem Cells