DNA makes RNA makes innate immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19665965.
- Also identified by DOI 10.1016/j.cell.2009.07.021.
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Abstract
Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.
Medical subject headings
- DNA
- Immunity, Innate
- RNA