A customized and versatile high-density genotyping array for the mouse.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19668205.
- Also identified by DOI 10.1038/nmeth.1359 and PMC identifier 2735580.
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Abstract
We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.
Medical subject headings
- Genotype
- Oligonucleotide Array Sequence Analysis