Three genes for enzymes of the pyruvate dehydrogenase complex map to human chromosomes 3, 7, and X.
basic_science · Level V
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- Record sourced from PubMed, PMID 1967901.
- Also identified by PMC identifier 1684992.
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Abstract
The genes for three proteins of the pyruvate dehydrogenase (PDH) complex have been assigned to human chromosomes by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these genes. PDH-E1 alpha has been localized on human chromosome 3p13-q23. The assignments of lipoamide dehydrogenase(E3) and PDH-E1 alpha [corrected] to chromosomes 7 and Xp, respectively, have been confirmed. Restrictive-fragment-length polymorphisms have been identified with E3, which will permit further localization of this gene by genetic linkage analysis.
Medical subject headings
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 7
- Genes
- Pyruvate Dehydrogenase Complex
- X Chromosome