Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-gamma receptor 1 deficiency.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19681704.
- Also identified by DOI 10.1086/605532 and PMC identifier 2730428.
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Abstract
Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-gamma receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-gamma axis appears to be critical for control of coccidioidomycosis.
Medical subject headings
- Coccidioidomycosis
- Genetic Predisposition to Disease
- Mycobacterium Infections
- Receptors, Interferon