Toxicodynamics of itraconazole: implications for therapeutic drug monitoring.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 19681707.
- Also identified by DOI 10.1086/605499.
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Abstract
We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.
Medical subject headings
- Antifungal Agents
- Drug Monitoring
- Gastrointestinal Diseases
- Itraconazole
- Water-Electrolyte Balance