Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 19681708.
- Also identified by DOI 10.1086/605497.
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Abstract
A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
Medical subject headings
- AIDS-Related Opportunistic Infections
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Immune Reconstitution Inflammatory Syndrome
- Meningitis, Cryptococcal