Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19684581.
- Also identified by DOI 10.1038/nm.1995.
- No licence information is recorded for this record.
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Abstract
T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.
Medical subject headings
- Animals
- Case-Control Studies
- Cell Proliferation
- Cell Proliferation/drug effects
- Disease Models, Animal
- Humans
- Hyperplasia
- Interleukins
- Interleukins/antagonists & inhibitors
- Interleukins/genetics
- Interleukins/pharmacology
- Interleukins/physiology
- Keratinocytes
- Keratinocytes/drug effects
- Keratinocytes/immunology
- Keratinocytes/pathology
- Keratinocytes/transplantation
- Mice
- Psoriasis
- Psoriasis/genetics
- Psoriasis/immunology
- Psoriasis/pathology
- Psoriasis/therapy
- RNA, Messenger
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Recombinant Proteins
- Recombinant Proteins/pharmacology
- T-Lymphocytes
- T-Lymphocytes/immunology
- Transplantation, Heterologous
- Interleukin-21