Surreptitious drug use by patients in a panic disorder study.

Clark, D B; Taylor, C B; Roth, W T; Hayward, C; Ehlers, A; Margraf, J; Agras, W S · Am J Psychiatry · 1990

rct · Level II

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Abstract

In a double-blind, placebo-controlled trial comparing alprazolam and imipramine for panic disorder, serum analysis revealed that a substantial proportion of the patients took explicitly prohibited anxiolytic medication. Excluding these patients changed the results.

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