Nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP offered as cell substrate: spacing determines attachment and differentiation of neurons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19694460.
- Also identified by DOI 10.1021/nl9023325.
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Abstract
The density/spacing of plasma membrane proteins is thought to be crucial for their function; clear-cut experimental evidence, however, is still rare. We examined nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP with respect to their impact on neuron attachment and neurite growth. Data analysis/modeling revealed that these cellular responses improve with increasing DM-GRASP density, with the exception of one spacing which does not allow for the anchorage of a cytoskeletal protein (spectrin) to three DM-GRASP molecules.
Medical subject headings
- Nanostructures
- Nanotechnology
- Neural Cell Adhesion Molecules
- Neurons
- Tissue Engineering